PROTAb Platform: An Innovative Universal Linker for DACs With CereblonBased Degraders
Time: 1:30 pm
day: Day One
Details:
- An introduction into PROTAb – Orum’s traceless linker technology for Degrader-Antibody Conjugate (DAC). It improves the effectiveness of cereblon-based degraders by enabling stable conjugation to therapeutic antibodies
- Understanding the technology used, including a Mannich base self-immolative spacer to form stable DAC, releasing the active degrader tracelessly upon intracellular triggering
- Reviewing the versatility and compatibility with various conjugation methods, and the enhancement of drug-like characteristics. This approach ensures effective targeted protein degradation in diverse cellular contexts
