Conditional Logic-Gated Bispecific ADCs: Harnessing Novel Dual Antigen Fingerprints to Expand Efficacy & Minimize On-Target/Off-Tissue Toxicity
- Conditional logic-gated bispecific ADCs offer a next-generation strategy for precise tumor targeting and improved efficacy in heterogeneous cancers
- By exploiting unique dual-antigen expression fingerprints, they enable selective payload delivery to malignant cells, enhancing potency while minimizing on-target/off-tissue toxicity
- Highlighting key design principles, preclinical validation, and translational insights demonstrating how logic-gated ADCs can overcome the limitations of conventional ADCs and expand therapeutic opportunities across difficult-to-treat tumors